Anti-leishmania Effect of Magnesium Oxide Nanoparticles on <i>Leishmania tropica/infantum</i> and <i>Leishmania</i>-Infected Macrophages

Background: Leishmania is an intracellular protozoan parasite that enters and reproduces in macrophage cells. Macrophages are important immune cells phagocyte many pathogens such as bacteria, fungi, parasites spp. but incapable of killing this parasite, living the phagosomes infected macrophages, multiplying, resulting divesting macrophages appearance lesions. Many present drugs for treatment have side effects, or resistance to some these drugs. Therefore, there a need better drug treatment. Magnesium oxide (MgO) metal nanoparticle (NP) with numerous biological applications, including antioxidant antimicrobial effects on various parasites, Objectives: Accordingly, article has discussed MgO NPs tropica infantum Leishmania-infected macrophages. Materials Methods: The effect doses L. promastigotes amastigotes was studied vitro. Flow cytometry MTT were also utilized assess cytotoxic promastigotes, well likelihood apoptosis. Amastigote assay employed determine percentage, number every cell. Results: percentage contaminated treated 15% 11%, respectively. revealed induced approximately 38.56% 30.5% apoptosis infantum, half maximal inhibitory concentration according promastigote 72 hours 7.32 μg/mL 12.58 μg/mL, Conclusion: According findings, had great in-vitro fatality (inside leishmania-infected macrophages).